李晨
编辑:2138cn太阳集团编辑  来源:2138cn太阳集团原创  浏览次数: 发布日期:2014-08-04 16:08:52 【

2008-2013年  南京农业大学预防兽医学,博士学位 

2014- 2017 滨州医学院代谢与神经精神疾病研究所,讲师

2017-2019,美国佐治亚州奥古斯塔大学(Augusta university)佐治亚医学院神经与再生医学系,博士后

2019-,滨州医学院代谢与神经精神疾病研究所,讲师

研究方向:博士期间研究宿主细胞RNA解旋酶在病毒感染中作用机制,涉及研究领域包括病毒学、细胞分子生物学及蛋白质结构生物学。目前研究课题为慢性应激所致抑郁障碍的表观遗传学。

代表论著:

1.     Chen Li*, Fantao Meng, Jacob C Garza, Jing Liu, Yun Lei, Sergei A Kirov, Ming Guo, Xin-Yun Lu*. Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons. 2020, Molecular psychiatry, doi: 10.1038/ s41380-020-0649-0.

2.     Ming Guo, Chen Li, Yun Lei, Shengmin Xu, Di Zhao, Xin-Yun Lu*. Role of the adipose PPARγ-adiponectin axis in susceptibility to stress and depression/ anxiety-related behaviors. Molecular psychiatry, 2017, 22(7):1056-1068.

3.     Yun Lei, Jian-gong Wang, Dan Wang, Chen Li, Bin Liu, Xing Fang, Jing-jing You, Ming Guo, Xin-Yun Lu*. SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex. 2019, Molecular psychiatry, doi: 10.1038/s41380-019-0352-1.

4.     Feng-jiao Sun, Yun Lei, Jing-jing You, Chen Li, Lin-shan Sun, Jacob Garza, Di Zhang, Ming Guo, Phillip E Scherer, Daniel Lodge, Xin-Yun Lu*. Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1. Molecular psychiatry, 2019 Jan;24(1):126-144.

5.     Chen Li*, Ling-ling Ge, Peng-peng Li, Yue Wang, Juan-juan Dai, Ming-xia Sun, Li Huang, Zhi-qiang Shen, Xiao-chun Hu, Hassan Ishag, Xiang Mao*. Cellular DDX3 regulates Japanese encephalitis virus replication by interacting with viral un-translated regions. Virology, 2014, 44, (9),70-81.

6.     Chen Li, Ling-ling Ge, Ya-ling Yu, Li Huang, Yue Wang, Ming-xia Sun, Hassan Ishag, Liang-xiao Ma, Xue-hua Li, Zhi-qiang Shen*, Xiang Mao*. A tripeptide (NSK) inhibits Japanese encephalitis virus infection in vitro and in vivo. Archives of Virology, 2014.159(5):1045-1055.

7.     Chen Li, Ling-ging Ge, Peng-peng Li, Yue Wang, Ming-xia Sun, Li Huang, Hassan Ishag, Dong-dong Di, Zhi-qiang Shen, Wei-xing Fan*, Xiang Mao*. The DEAD-box RNA helicase DDX5 acts as a positive regulator of Japanese encephalitis virus replication by binding to viral 3' UTR. Antiviral Research, 2013, 100, (2), 487-499.

8.     Chen Li, Li-ying Zhang, Peng-peng Li, Ming-Xia Sun, Li Huang, Jian-chao Wei, Yi-lin Yao, Hassan Ishag, Pu-yan Chen*, Xiang Mao*. Inhibition of Japanese Encephalitis Virus Entry into the Cells by the Envelope glycoprotein Domain III (EDIII) and the Loop 3 Peptide Derived From EDIII. Antiviral Research, 2012, 94(2):179-183.

9.     Hassan. A. Ishag, Chen Li, Li, Huang, Ming-xia Sun, Fang quan Wang, Bo Ni, Pu-yan Chen, Xiang Mao*. Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo. Archives of Virology, 2013, 158(2):349-358.

10.  Hassan Z.A. Ishag, Chen Li, Li Huang, Xiang Mao*. 2012. Inhibition of Japanese encephalitis virus infection in vitro and in vivo by Pokeweed Antiviral Protein. Virus Research, 2013, 171(1):89-96.

11.  Hassan Ishag*, Chen Li, Fengjuan Wang, Xiang Mao*, Griffithsin binds to the glycosylated proteins (E and prM) of Japanese encephalitis virus and inhibit its infection. Virus Research, 2016, 215: 50-54.

12.  Ming-xia Sun, Li Huang, Rui Wang, Ya-ling Yu, Chen Li, Peng-peng Li, Xiang Mao*. Porcine Reproductive and Respiratory syndrome Virus Induce Autophagy to Promote Virus Replication. Autophagy.2012, 1; 8(10):1434-47.

13.  Li Huang, Yuan-peng Zhang, Ya-ling Yu, Ming-xia Sun, Chen Li, Bo Ni, Xiu-hua Wang, Pu-yan Chen, Xiang Mao*. Role of cholesterol in porcine reproductive and respiratory syndrome virus (PRRSV) infection on MARC-145 cells. Biochemical and Biophysical Research Communications, 2011,414:545-550.

14.  Yue Wang, Jia-rong Li, Ming-xia Sun, Bo Ni, Chang-chao Huan, Li Huang, Chen Li, Fan Hong-jie, Xiao-feng Ren*, Xiang Mao*. Antiviral Research.2014, 106 :33-41.

承担课题:

1.国家自然科学基金项目:中缝背核5-HT神经元中AdipoR1对应激易感性和抑郁行为调控的研究(81601189)。立项时间:2017-2019年,负责人:李晨。

2.山东省自然科学基金青年基金项目:瘦素对BDNF基因转录的表观遗传学调控在其抗抑郁机制中的作用(ZR2014HQ080)。立项时间:2014-2016年,负责人:李晨。 

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