郭明
编辑:2138cn太阳集团编辑  来源:2138cn太阳集团原创  浏览次数: 发布日期:2013-09-03 17:43:22 【

1997-2001 沈阳药科大学,药学学士

2001-2005  沈阳药科大学, 药理学博士 

2005-2007  香港中文大学, 研究助理 

2012-present  滨州医学院代谢与神经精神疾病研究所, 副教授,副所长 

研究方向:

瘦素受体信号传导系统在情绪行为调控中的作用:应用瘦素受体酪氨酸磷酸化位点敲除小鼠模型,采用行为学、分子生物学、电生理等实验方法探讨瘦素作用机制。

代表论著:

1.Guo M , Li C , Lei Y , Xu S , Zhao D , Lu XY* (2016). Role of the adipose PPARγ-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors.Mol Psychiatry. 2016 Dec 13. doi: 10.1038/mp.2016.225. [Epub ahead of print]

2. Liu J, Guo M, Lu XY* (2015) Leptin/LepRb in the ventral tegmental area mediates anxiety-related behaviors. Int J Neuropsychopharmacol. 2015 in press. 

3.Guo M, Lu XY. Leptin receptor deficiency confers resistance to behavioral effects of fluoxetine and desipramine via separable substrates.Translational Psychiatry (2014) 4, e486;doi:10.1038/tp.2014.126    

4. Guo M, Huang TY, Garza JC, Chua SC, Lu XY. Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours. Int J Neuropsychopharmacol. 2013 May; 16(4):857-67.    

5. Liu J, Guo M, Zhang D, Cheng SY, Liu M, Ding J, Scherer PE, Liu F, Lu XY. Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12248-53.   

6. Guo M, Lu Y, Garza JC, Li Y, Chua SC, Zhang W, Lu B, Lu XY. Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression. Transl Psychiatry. 2012; 2:e83.    

7. Garza JC, Guo M, Zhang W, Lu XY. Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β-catenin signaling. Mol Psychiatry. 2012 Jul; 17(8):790-808.    

8. Zhang D, Guo M(共同第一编辑), Zhang W, Lu XY. Adiponectin stimulates proliferation of adult hippocampal neural stem/progenitor cells through activation of p38 mitogen-activated protein kinase (p38MAPK)/glycogen synthase kinase 3β (GSK-3β)/β-catenin signaling cascade. J Biol Chem. 2011 Dec 30; 286(52):44913-20.   

9. Yu T, Guo M, Garza J, Rendon S, Sun XL, Zhang W, Lu XY. Cognitive and neural correlates of depression-like behaviour in socially defeated mice: an animal model of depression with cognitive dysfunction. Int J Neuropsychopharmacol. 2011 Apr;14(3):303-17.    

10. Garza JC, Guo M, Zhang W, Lu XY. Leptin increases adult hippocampal neurogenesis in vivo and in vitro. J Biol Chem.2008 Jun 27; 283(26):18238-47.    

11. Guo M, Xu NJ, Li YT, Yang JY, Wu CF, Pei G. Morphine modulates glutamate release in the hippocampal CA1 area in mice.Neurosci Lett. 2005 Jun 10-17; 381(1-2):12-5.    

12. Hao Y, Yang JY, Guo M, Wu CF, Wu MF. Morphine decreases extracellular levels of glutamate in the anterior cingulate cortex: an in vivo microdialysis study in freely moving rats. Brain Res. 2005 Apr 8;1040 (1-2):191-6.   

13. Guo M, Wu CF, Wang JH, Pei G. Effects of ginsenosides on the actions of morphine. Zhongguo Zhong Yao Za Zhi. 2004 Apr; 29(4):299-301. Review. Chinese.    

14. Guo M, Wang JH, Yang JY, Zhu D, Xu NJ, Pei G, Wu CF, Li X. Roles of ginsenosides on morphine-induced hyperactivity and rewarding effect in mice. Planta Med. 2004 Jul; 70(7):688-90.   

15. Guo M, Wu CF, Liu W, Yang JY, Chen D. Sex difference in psychological behavior changes induced by long-term social isolation in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jan; 28(1):115-21.   


承担课题:

1.国家自然科学基金项目: VTA瘦素敏感神经元投射到杏仁核和终纹床核的神经通路对焦虑行为和HPA轴的调节作用及机制研究。立项时间2018-2021年,负责人:郭明。

2.国家自然科学基金项目: 瘦素受体酪氨酸磷酸化位点在情绪行为调控中的作用和信号传导机制研究(81301164)。立项时间:2014-2016年,负责人:郭明。

3.烟台市科技发展计划项目:瘦素对海马5-羟色胺神经递质传递的影响。立项时间:2013-2017年,负责人:郭明。

4.教育部留学回国人员科研启动基金项目:瘦素与氟西汀的抗抑郁作用及对海马谷氨酸手提系统影响的比较。立项时间:2013年,负责人:郭明。

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